LncRNA FBXL19-AS1 promotes proliferation and metastasis of cervical cancer through upregulating COL1A1 as a sponge of miR-193a-5p

Abstract Background Cervical cancer (CC) is one of the most common and malignant tumors in women. In this study, we aim to explore role mechanism F-box leucine rich repeat protein 19 antisense RNA 1 (FBXL19-AS1), a novel long-chain non coding (lncRNA) with marked roles variety tumors, regulating proliferation metastasis CC. Methods The expression FBXL19-AS1, miR-193a-5p COL1A1 were detected by RT-PCR western blot. Gain- loss-of functional assays FBXL19-AS1 performed CC cell lines vitro or vivo. proliferation, migration, invasion, apoptosis epithelial-mesenchymal transition (EMT) cells determined. Results significantly up-regulated tissues, while was down-regulated. Overexpression promoted EMT growth inhibited apoptosis, knockdown had opposite effects. On other hand, cells. Mechanistically, functioned as competitive endogenous (ceRNA) miR-193a-5p, which targeted at 3’-UTR site negatively regulated expression. Conclusions promotes sponging up-regulating COL1A1.